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Article

Regulation of lipids is central to replicative senescence

19 Jan 2017

Abstract excerpt

Cellular replicative senescence, a state of permanent cell-cycle arrest, has been linked to organismal aging, tissue repair and tumorigenesis. In this study, we comparatively investigated the global lipid profiles and mRNA content of proliferating and senescent-state BJ fibroblasts. We found that both expression levels of lipid-regulating genes and the abundance of specific lipid families, are actively regulated....

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PMID: 28128379
DOI: 10.1039/c6mb00842a

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