Article
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
The Journal of cell biology - 3 Jul 2017
Carroll Bernadette, Nelson Glyn, Rabanal-Ruiz Yoana, Kucheryavenko Olena, Dunhill-Turner Natasha A, Chesterman Charlotte C, Zahari Qabil, Zhang Tong, Conduit Sarah E, Mitchell Christina A, Maddocks Oliver D K, Lovat Penny, von Zglinicki Thomas, Korolchuk Viktor I
Abstract excerpt
Mammalian target of rapamycin complex 1 (mTORC1) and cell senescence are intimately linked to each other and to organismal aging. Inhibition of mTORC1 is the best-known intervention to extend lifespan, and recent evidence suggests that clearance of senescent cells can also improve health and lifespan. Enhanced mTORC1 activity drives characteristic phenotypes of senescence, although the underlying mechanisms...
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