Article

Development of an in vitro senescent hepatic cell model for metabolic studies in aging

2020-03-31

Abstract excerpt

Although aging in the liver contributes to the development of chronic liver diseases such as NAFLD and insulin resistance, little known about the molecular and metabolic details of aging in hepatic cells. To examine these issues, we used sequential oxidative stress with hydrogen peroxide to induce premature senescence in AML12 hepatic cells. The senescent cells exhibited molecular and metabolic signatures, increas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6fbfec64-da60-5fc0-9aa4-d4a26c12700a
DOI: 10.1101/2020.03.31.014035

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of an in vitro senescent hepatic cell model for metabolic studies in agingDOI 10.1101/2020.03.31.014035Read

Decreased autophagy and fuel switching occur in a senescent hepatic cell model system.Semantic proximity Read

The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular CarcinomaSemantic proximity Read

Cell Senescence, DNA Damage, and Metabolism.Semantic proximity Read

Targeting metabolism in cellular senescence, a role for intervention.Semantic proximity Read

Aging and Aging-Related Senescence in LiverSemantic proximity Read

The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)Semantic proximity Read

Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuliSemantic proximity Read

Cellular senescence: Implications for metabolic disease.Semantic proximity Read

Mitochondria are required for pro-ageing features of the senescent phenotype.Semantic proximity Read

Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implicationsSemantic proximity Read

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration.Semantic proximity Read

Evaluating causality of cellular senescence in non-alcoholic fatty liver diseaseSemantic proximity Read