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Article

Decreased autophagy and fuel switching occur in a senescent hepatic cell model system.

Aging - 26 Jul 2020

Singh Brijesh Kumar, Tripathi Madhulika, Sandireddy Reddemma, Tikno Keziah, Zhou Jin, Yen Paul Michael

Abstract excerpt

Although aging in the liver contributes to the development of chronic liver diseases such as NAFLD and insulin resistance, little is known about the molecular and metabolic details of aging in hepatic cells. To examine these issues, we used sequential oxidative stress with hydrogen peroxide to induce premature senescence in AML12 hepatic cells. The senescent cells exhibited molecular and metabolic signatures,...

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Identifiers

PMID: 32712601
DOI: 10.18632/aging.103740
PMCID: PMC7425478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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