Article

Inhibition of <i>de novo</i> ceramide biosynthesis affects aging phenotype in an <i>in vitro</i> model of neuronal senescence

2019-05-23

Abstract excerpt

Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be delayed, counteracted, if not completely interrupted. Aging is the primary risk factor for the onset and development of neurodegenerative conditions like Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis. Intracellular calcium (Ca 2+ i ) dyshomeostasis, mitochondrial dys...

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Literature Corpus work: f8fb6c94-3dcb-50dc-834e-546271bbe4cb
DOI: 10.1101/645879

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