Article

Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

2022-08-01

Abstract excerpt

<h4>ABSTRACT</h4> Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senescence-associated secretory phenotype (SASP). However, the mechanisms involved in the conversion of damaged cells into senescent cells remain incompletely underst...

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Literature Corpus work: 0fec75b7-1863-55df-8479-f65226c2315f
DOI: 10.1101/2022.07.29.501953

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