Article

Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

2017-10-15

Abstract excerpt

There is increasing evidence that many GWAS risk loci are molecular QTL for gene ex-pression (eQTL), histone modification (hQTL), splicing (sQTL), and/or DNA methylation (meQTL). Here, we introduce a new set of functional annotations based on causal posterior prob-abilities (CPP) of fine-mapped molecular cis-QTL, using data from the GTEx and BLUEPRINT consortia. We show that these annotations are very strongly enr...

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Literature Corpus work: 2f7f9e09-bf42-5bc3-8318-fbae394e96af
DOI: 10.1101/203380

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