Article

Hypomorphic NOTCH1 Expression Alters Cardiomyocyte Cellular Architecture in Hypoplastic Left Heart Syndrome

2024-10-01

Abstract excerpt

<h4>Summary</h4> NOTCH1 is a protein involved in cardiac development and mutations in NOTCH1 are implicated in left sided congenital heart disease, including hypoplastic left heart syndrome (HLHS). Therapeutic advances for HLHS patients have been hampered by the absence of suitable experimental models. Here, using human induced pluripotent stem cells (hiPSCs), we have generated a series of CRISPR-edited complex h...

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Literature Corpus work: ed005af9-c589-5e0a-a463-94e2ad7e0ea3
DOI: 10.1101/2024.09.30.615809

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