Article

SNTA1 Gene Rescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with Arrhythmias

2022-01-26

Abstract excerpt

Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown. We aimed to determine the role of cardiac ion channels controlling cardiac excitability in the mechanisms of arrhythmias in DMD patients. To test whether cardiac dystrophin mutations lead to defective Na V 1.5–Kir2.1 channelosomes and arrhythmias, we generated i...

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Literature Corpus work: 2e91a0fb-551b-53e1-a051-fae19cc3dd3c
DOI: 10.1101/2022.01.25.477696

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SNTA1 Gene Rescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with ArrhythmiasDOI 10.1101/2022.01.25.477696Read

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