Analyses of methyltransferases across the pathogenicity spectrum of different mycobacterial species point to an extremophile connection

Abstract excerpt

Tuberculosis is a devastating disease, taking one human life every 20 seconds globally. We hypothesize that professional pathogens such as M.tb have acquired specific features that might assist in causing infection, persistence and transmissible pathology in their host. We have identified 121 methyltransferases (MTases) in the M.tb proteome, which use a variety of substrates - DNA, RNA, protein, intermediates of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Molecular Research
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology