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Quinazoline-quinoline bisubstrate inhibitors target eukaryotic translation initiation factor 3 in <i>Plasmodium falciparum</i>

2022-12-11

Abstract excerpt

Malaria drug resistance is hampering the fight against the deadliest parasitic disease affecting over 200 million people worldwide. We recently developed quinoline-quinazoline-based inhibitors (as compound 70 ) as promising new antimalarials. Here we aimed to investigate their mechanism of action by using Thermal Proteome Profiling (TPP). The eukaryotic translation initiation factor 3 (EIF3i) subunit I was identi...

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Literature Corpus work
db0b3204-4b53-592a-b0bf-7908a334fdab
DOI
10.1101/2022.12.10.519887
Open publication

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Quinazoline-quinoline bisubstrate inhibitors target eukaryotic translation initiation factor 3 in <i>Plasmodium falciparum</i>DOI 10.1101/2022.12.10.519887
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