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Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection

18 May 2018

Abstract excerpt

Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria.Here, we use RNA-sequencing to identify host genes that are upregulated upon Plasmodium berghei infection of hepatocytes with the hypothesis that host pathways are hijacked to benefit parasite development.We found that expression of aquaporin-3 (AQP3), a water and glycerol channel, is significantly...

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PMID: 29775485
DOI: 10.1371/journal.ppat.1007057

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