Article

Transcriptional Responses to Bumped Kinase Inhibitor BKI-1708 in <em>Toxoplasma gondii</em> and Human Fibroblasts

2026-06-08

Abstract excerpt

Bumped kinase inhibitors exhibit proven safety and promising efficacy against apicomplexan parasites in both in vitro and in vivo studies. The 5-aminopyrazole-4-carboxamide compound BKI-1708 effectively inhibited the vertical transmission of Toxoplasma gondii and significantly reduced the cerebral parasite loads in experimentally infected pregnant mice. In vitro experiments revealed that exposure of T. gondii tach...

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Literature Corpus work: ee00f8c0-3004-5136-80a5-907fdcf48637
DOI: 10.20944/preprints202606.0507.v1

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