Establishment and Application of a High Throughput Screening System Targeting the Interaction between HCV Internal Ribosome Entry Site and Human Eukaryotic Translation Initiation Factor 3

Abstract excerpt

Viruses are intracellular obligate parasites, which have evolved to exploit the host cellular machinery for their replication. Human eukaryotic translation initiation factor 3 (eIF3) could be directly recruited by the HCV internal ribosome entry site (IRES) to promote the translation of viral proteins. In this study, we establish a fluorescence polarization (FP) based high throughput screening (HTS) system...

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