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The potent <i>Toxoplasma gondii</i> growth inhibitor QQ-437 does not bind to its predicted target, parasite adaptin3 <i>β</i> , in yeast three-hybrid assays

2022-06-08

Abstract excerpt

New drugs are needed to treat infections with Toxoplasma gondii , a ubiquitous protozoan parasite that can cause miscarriage, blindness, and life-threatening encephalitis in its human hosts. A novel N-benzoyl-2-hydroxybenzamide named QQ-437 was recently shown to be a potent inhibitor of T. gondii growth in vitro (EC 50 = 16nM), and to reduce parasite load in a mouse model of infection. Intriguingly, mutations...

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Identifiers and source

Literature Corpus work
91391322-095b-50f2-af42-d051fc470688
DOI
10.1101/2022.06.07.495217
Open publication

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The potent <i>Toxoplasma gondii</i> growth inhibitor QQ-437 does not bind to its predicted target, parasite adaptin3 <i>β</i> , in yeast three-hybrid assaysDOI 10.1101/2022.06.07.495217
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