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Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells

19 Nov 2020

Abstract excerpt

The malaria parasite Plasmodium obligatorily infects and replicates inside hepatocytes surrounded by a parasitophorous vacuole membrane (PVM), which is decorated by the host-cell derived autophagy protein LC3. We have previously shown that the parasite-derived, PVM-resident protein UIS3 sequesters LC3 to avoid parasite elimination by autophagy from hepatocytes. Here we show that a small molecule capable of...

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PMID: 33214643
DOI: 10.1038/s42003-020-01422-1

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