Article

A high-throughput <i>in vitro</i> translation screen towards discovery of novel antimalarial protein translation inhibitors

2018-01-16

Abstract excerpt

<h4>ABSTRACT</h4> Drugs that target protein synthesis are well-validated for use as antimicrobials, yet specific high throughput (HTP) methods to screen for those targeting malaria are lacking. Here, we have developed a cell free in vitro translation (IVT) assay for the human malaria parasite, Plasmodium falciparum , which reconstitutes the native parasite protein translation machinery. Combining clarified IVT...

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Literature Corpus work: 07cf9096-9814-5131-b513-af1154f9cc41
DOI: 10.1101/248740

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