Article

Enzymes define pathways and metabolic relationships

2025-06-19

Abstract excerpt

Gene-centric pathway mapping tools, widely used to interpret untargeted liquid chromatography mass spectrometry (LC-MS) metabolomics data, may underperform because a single metabolite can generate multiple spectral features, inflating false positive rates. Classic enzymology, which established metabolite flow before gene sequencing, offers experimentally validated precursor-product relationships that could overcom...

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Literature Corpus work: db031cca-ba71-5169-b031-379c2117115c
DOI: 10.1101/2025.06.16.657199

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