Article
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma.
Cell metabolism - 5 Sept 2023
Benson Mark D, Eisman Aaron S, Tahir Usman A, Katz Daniel H, Deng Shuliang, Ngo Debby, Robbins Jeremy M, Hofmann Alissa, Shi Xu, Zheng Shuning, Keyes Michelle, Yu Zhi, Gao Yan, Farrell Laurie, Shen Dongxiao, Chen Zsu-Zsu, Cruz Daniel E, Sims Mario, Correa Adolfo, Tracy Russell P, Durda Peter, Taylor Kent D, Liu Yongmei, Johnson W Craig, Guo Xiuqing, Yao Jie, Chen Yii-Der Ida, Manichaikul Ani W, Jain Deepti, Yang Qiong, Bouchard Claude, Sarzynski Mark A, Rich Stephen S, Rotter Jerome I, Wang Thomas J, Wilson James G, Clish Clary B, Sarkar Indra Neil, Natarajan Pradeep, Gerszten Robert E
Abstract excerpt
Although many novel gene-metabolite and gene-protein associations have been identified using high-throughput biochemical profiling, systematic studies that leverage human genetics to illuminate causal relationships between circulating proteins and metabolites are lacking. Here, we performed protein-metabolite association studies in 3,626 plasma samples from three human cohorts. We detected 171,800 significant...
Topics
- Humans
- Animals
- Mice
- Proteomics
- Metabolomics
- Signal Transduction
- Genome-Wide Association Study