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Article

Neuroticism polygenic risk predicts conversion from mild cognitive impairment to Alzheimer's disease by impairing inferior parietal surface area.

Human brain mapping - 1 May 2024

Li Qiaojun, Lv Xingping, Qian Qian, Liao Kun, Du Xin

Abstract excerpt

The high prevalence of conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD) makes early prevention of AD extremely critical. Neuroticism, a heritable personality trait associated with mental health, has been considered a risk factor for conversion from aMCI to AD. However, whether the neuroticism genetic risk could predict the conversion of aMCI and its underlying neural...

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Identifiers

PMID: 38746977
DOI: 10.1002/hbm.26709
PMCID: PMC11094517

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