Article
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
eLife - 1 Oct 2020
Zhang Hao, Zhang Yang, Zhou Xinyue, Wright Shaela, Hyle Judith, Zhao Lianzhong, An Jie, Zhao Xujie, Shao Ying, Xu Beisi, Lee Hyeong-Min, Chen Taosheng, Zhou Yang, Chen Xiang, Lu Rui, Li Chunliang
Abstract excerpt
Aberrant HOXA9 expression is a hallmark of most aggressive acute leukemias, notably those with KMT2A (MLL) gene rearrangements. HOXA9 overexpression not only predicts poor diagnosis and outcome but also plays a critical role in leukemia transformation and maintenance. However, our current understanding of HOXA9 regulation in leukemia is limited, hindering development of therapeutic strategies. Here, we generated...
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