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Article

Deregulation of the HOXA9/MEIS1 axis in acute leukemia.

Current opinion in hematology - 1 Jul 2016

Collins Cailin T, Hess Jay L

Abstract excerpt

PURPOSE OF REVIEW: HOXA9 is a homeodomain transcription factor that plays an essential role in normal hematopoiesis and acute leukemia, in which its overexpression is strongly correlated with poor prognosis. The present review highlights recent advances in the understanding of genetic alterations leading to deregulation of HOXA9 and the downstream mechanisms of HOXA9-mediated transformation. RECENT FINDINGS: A...

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Topics

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Share to Nucleophosmin
Share to Cell Transformation, Neoplastic
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia

Share to Myeloid Ecotropic Viral Integration Site 1 Protein

Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27258906
DOI: 10.1097/MOH.0000000000000245
PMCID: PMC5653247

Genes

HOXA9
CDX4
IGF1
MEIS1
NPM1
NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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