Article

Natural IgA and <i>TNFRSF13B</i> polymorphism: a double edged sword fueling balancing selection

2021-01-31

Abstract excerpt

TNFRSF13B encodes the “transmembrane-activator and CAML-interactor” (TACI) receptor, which drives plasma cell differentiation. Although TNFRSF13B supports host defense, dominant-negative TNFRSF13B alleles are common in humans and other species and only rarely associate with disease. We reasoned the high frequency of disruptive TNFRSF13B alleles reflects balancing selection, the loss of function conferring advan...

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Literature Corpus work: daeacd4c-383a-58e6-bba4-95c2538ea273
DOI: 10.1101/2021.01.29.428850

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