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Article

TACI is mutant in common variable immunodeficiency and IgA deficiency.

Nature genetics - 1 Aug 2005

Castigli Emanuela, Wilson Stephen A, Garibyan Lilit, Rachid Rima, Bonilla Francisco, Schneider Lynda, Geha Raif S

Abstract excerpt

The tumor necrosis factor receptor family member TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) mediates isotype switching in B cells. We found that 4 of 19 unrelated individuals with common variable immunodeficiency (CVID) and 1 of 16 individuals with IgA deficiency (IgAD) had a missense mutation in one allele of TNFRSF13B (encoding TACI). One of the four individuals with...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to IgA Deficiency

Share to Immunoglobulins

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Share to Receptors, Tumor Necrosis Factor

Share to Transmembrane Activator and CAML Interactor Protein

Source

Identifiers

PMID: 16007086
DOI: 10.1038/ng1601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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