Article
TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.
JCI insight - 22 Jul 2021
Platt Jeffrey L, de Mattos Barbosa Mayara Garcia, Huynh Daniel, Lefferts Adam R, Katta Juhi, Kharas Cyra, Freddolino Peter, Bassis Christine M, Wobus Christiane, Geha Raif, Bram Richard, Nunez Gabriel, Kamada Nobuhiko, Cascalho Marilia
Abstract excerpt
TNFRSF13B encodes the transmembrane activator and CAML interactor (TACI) receptor, which drives plasma cell differentiation. Although TNFRSF13B supports host defense, dominant-negative TNFRSF13B alleles are common in humans and other species and only rarely associate with disease. We reasoned that the high frequency of disruptive TNFRSF13B alleles reflects balancing selection, the loss of function conferring...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.