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Article

TNFRSF13B Diversification Fueled by B Cell Responses to Environmental Challenges-A Hypothesis.

Frontiers in immunology - 1 Jan 2021

Cascalho Marilia, Platt Jeffrey L

Abstract excerpt

B cell differentiation and memory are controlled by the transmembrane activator and CAML interactor (TACI), a receptor encoded by TNFRSF13B. TNFRSF13B mutations are frequently found in common variable immunodeficiency (CVID) and in IgA -deficiency; yet, ~98% of those with mutant TNFRSF13B are healthy. Indeed, TNFRSF13B is among the 5% most polymorphic genes in man. Other mammals evidence polymorphism at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33679786
DOI: 10.3389/fimmu.2021.634544
PMCID: PMC7925820

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