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Article

De novo discovery of mutated driver pathways in cancer.

Genome research - 1 Feb 2012

Vandin Fabio, Upfal Eli, Raphael Benjamin J

Abstract excerpt

Next-generation DNA sequencing technologies are enabling genome-wide measurements of somatic mutations in large numbers of cancer patients. A major challenge in the interpretation of these data is to distinguish functional "driver mutations" important for cancer development from random "passenger mutations." A common approach for identifying driver mutations is to find genes that are mutated at significant...

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PMID: 21653252
DOI: 10.1101/gr.120477.111
PMCID: PMC3266044

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