Article

Adaptation of a Mutual Exclusivity Framework to Identify Driver Mutations within Biological Pathways

2023-09-22

Abstract excerpt

Distinguishing genomic alterations in cancer genes that have functional impact on tumor growth and disease progression from the ones that are passengers and confer no fitness advantage has important clinical implications. Evidence-based methods for nominating drivers are limited by existing knowledge on the oncogenic effects and therapeutic benefits of specific variants from clinical trials or experimental setting...

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Literature Corpus work: 8046d19c-9f09-5747-af81-21d70a6e9560
DOI: 10.1101/2023.09.19.558469

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