Article

A Bayesian Approach for Identifying Driver Mutations within Oncogenic Pathways through Mutual Exclusivity

2025-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Distinguishing driver mutations from the large background of passenger mutations remains a major challenge in cancer genomics. Evidence-based approaches to nominate driver mutations are often limited by the availability of experimental or clinical validation for specific variants. As clinical sequencing becomes integrated into patient care, computational methods provide powerful opportunities to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c402d32e-d607-54f0-8b43-be70d2013f08
DOI: 10.1101/2025.05.27.656485

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Bayesian Approach for Identifying Driver Mutations within Oncogenic Pathways through Mutual ExclusivityDOI 10.1101/2025.05.27.656485Read

Adaptation of a mutual exclusivity framework to identify driver mutations within oncogenic pathways.Semantic proximity Read

Adaptation of a Mutual Exclusivity Framework to Identify Driver Mutations within Biological PathwaysSemantic proximity Read

Cancer driver mutation prediction through Bayesian integration of multi-omic data.Semantic proximity Read

Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework.Semantic proximity Read

Driver gene detection through Bayesian network integration of mutation and expression profiles.Semantic proximity Read

Cancer driver mutations: predictions and reality.Semantic proximity Read

A latent variable model for evaluating mutual exclusivity and co-occurrence between driver mutations in cancerSemantic proximity Read

Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysis.Semantic proximity Read

Advancing cancer driver gene identification through an integrative network and pathway approach.Semantic proximity Read

WeSME: uncovering mutual exclusivity of cancer drivers and beyond.Semantic proximity Read

De novo discovery of mutated driver pathways in cancer.Semantic proximity Read

Combined burden and functional impact tests for cancer driver discovery using DriverPower.Semantic proximity Read