Back to search

Article

Lathosterol oxidase (sterol C5-desaturase) deletion confers resistance to amphotericin B and sensitivity to acidic stress in <i>Leishmania major</i>

2020-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Lathosterol oxidase (LSO) catalyzes the formation of C5-C6 double bond in the synthesis of various types of sterols in mammals, fungi, plants and protozoa. In Leishmania parasites, mutations in LSO or other sterol biosynthetic genes are associated with amphotericin B resistance. To investigate the biological roles of sterol C5-C6 desaturation, we generated a LSO -null mutant line ( lso – ) i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
abefc348-947d-51f9-bf70-f6a586d6e31a
DOI
10.1101/2020.04.20.051540
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Lathosterol oxidase (sterol C5-desaturase) deletion confers resistance to amphotericin B and sensitivity to acidic stress in <i>Leishmania major</i>DOI 10.1101/2020.04.20.051540
Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major.Semantic proximity
Sterol 14-α-demethylase is vital for mitochondrial functions and stress tolerance in <i>Leishmania major</i>Semantic proximity
Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania majorSemantic proximity
Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.Semantic proximity
Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasitesSemantic proximity
Sphingolipids protect ergosterol in the <i>Leishmania major</i> membrane from sterol-specific toxinsSemantic proximity
Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasitesSemantic proximity
The flexibility of Apicomplexa parasites in lipid metabolismSemantic proximity
Genetic profiling of the isoprenoid and sterol biosynthesis pathways of Trypanosoma cruziSemantic proximity
<i>Plasmodium falciparum</i> diacylglycerol acyltransferase maintains phospholipid homeostasis to regulate sexual differentiation, ER stress, and cytoadhesionSemantic proximity
Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.Semantic proximity
TransLeish: Identification of membrane transporters essential for survival of intracellular <i>Leishmania</i> parasites in a systematic gene deletion screenSemantic proximity
Select a neighboring publication to make it the new centre.