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Lipid Flippase Mediated Membrane Asymmetry Governs Extracellular Vesicles Biogenesis and Host Interactions in <i>Cryptococcus neoformans</i>

2026-06-13

Abstract excerpt

Cryptococcus neoformans is the leading cause of fungal meningitis in immunocompromised patients. Alveolar macrophages are the first line of defense against Cryptococcus infection. Our previous study showed that deletion of Cdc50, the regulatory subunit of P4-ATPase (lipid flippase) complex, results in increased phagocytosis and macrophage killing, and avirulence in animal models. However, how fungal flippase dysf...

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Literature Corpus work
7ccf8fe6-f47c-5fbd-9a8a-d4aa8e51edea
DOI
10.64898/2026.06.12.731820
Open publication

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Lipid Flippase Mediated Membrane Asymmetry Governs Extracellular Vesicles Biogenesis and Host Interactions in <i>Cryptococcus neoformans</i>DOI 10.64898/2026.06.12.731820
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