<i>PTPN11</i> /SHP2 negatively regulates growth in breast epithelial cells: implications on tumorigenesis

Abstract excerpt

PTPN11/SHP2, a non-receptor protein tyrosine phosphatase is a prominent target of the receptor tyrosine kinase that participates in positive feedback signalling of the human epidermal growth factor receptors and helps in growth and migration. PTPN11/SHP2 is widely believed to be an oncoprotein, although it’s possible tumor-suppressor role is also reported. Our analysis of breast cancer metadata shows, PTPN11/SHP2...

Topics

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• Apoptosis
• DNA Damage
• Drug Resistance, Neoplasm
• Mutation
• Neoplasms
• Noonan Syndrome
• Protein Tyrosine Phosphatase, Non-Receptor Type 11
• Protein Tyrosine Phosphatases

Identifiers and source

Literature Corpus work

daab1f0c-5d3f-5a43-b7f9-24c2c9a6649d

DOI

10.1101/2020.07.30.228445