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Article

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

Cancer metastasis reviews - 1 Jun 2008

Chan Gordon, Kalaitzidis Demetrios, Neel Benjamin G

Abstract excerpt

Diverse cellular processes are regulated by tyrosyl phosphorylation, which is controlled by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). De-regulated tyrosyl phosphorylation, evoked by gain-of-function mutations and/or over-expression of PTKs, contributes to the pathogenesis of many cancers and other human diseases. PTPs, because they oppose the action of PTKs, had been considered to...

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Source

Identifiers

PMID: 18286234
DOI: 10.1007/s10555-008-9126-y

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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