The tyrosine phosphatase Shp2 (PTPN11) in cancer.

doi:10.1007/s10555-008-9126-y

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Article

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

Cancer metastasis reviews - 1 Jun 2008

Chan Gordon, Kalaitzidis Demetrios, Neel Benjamin G

Abstract excerpt

Diverse cellular processes are regulated by tyrosyl phosphorylation, which is controlled by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). De-regulated tyrosyl phosphorylation, evoked by gain-of-function mutations and/or over-expression of PTKs, contributes to the pathogenesis of many cancers and other human diseases. PTPs, because they oppose the action of PTKs, had been considered to...

Topics

Animals
Cell Transformation, Neoplastic
Humans
LEOPARD Syndrome
Mutation
Neoplasms
Noonan Syndrome
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Proto-Oncogene Mas
Proto-Oncogene Proteins
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 18286234
DOI: 10.1007/s10555-008-9126-y

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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