Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy

doi:10.3390/ijms18061234

Article

Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy

8 Jun 2017

Abstract excerpt

The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1 (SHP-1), a non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of phosphorylated signal transducer and activator of transcription 3 (STAT3) and linked to tumor development. In this present review, we will discuss the importance and function of SHP-1/p-STAT3 signaling in nonmalignant conditions as well as...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.