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Article

The role of Shp2 (PTPN11) in cancer.

Current opinion in genetics & development - 1 Feb 2007

Mohi M Golam, Neel Benjamin G

Abstract excerpt

Tyrosyl phosphorylation, which is controlled by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs), regulates numerous cellular processes. Altered expression and/or mutations in PTKs are linked to many forms of cancer, yet until recently little was known about the roles of PTPs in normal cells or in cancer. Earlier work established that a member of the PTP superfamily, PTEN, is an important...

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Source

Identifiers

PMID: 17227708
DOI: 10.1016/j.gde.2006.12.011

Genes

PTEN
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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