PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.

doi:10.1182/blood-2006-07-028829

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Article

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.

Blood - 1 Feb 2007

Chan Rebecca J, Feng Gen-Sheng

Abstract excerpt

Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogenes and tumor suppressor genes. One new advance in this field is the identification of PTPN11 as the first proto-oncogene that encodes a cytoplasmic tyrosine phosphatase with 2 Src-homology 2 (SH2) domains (Shp2). This tyrosine phosphatase was previously shown to play...

Topics

Hematopoiesis
Humans
Intracellular Signaling Peptides and Proteins
Mutation
Noonan Syndrome
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatases
Proto-Oncogene Mas
Proto-Oncogene Proteins
Signal Transduction

Source

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Identifiers

PMID: 17053061
DOI: 10.1182/blood-2006-07-028829
PMCID: PMC1785139

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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