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Article

The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer

7 Nov 2018

Abstract excerpt

Role of Shp2: The dysregulation of cell signaling cascades associated with the cell differentiation and growth, due to the deletion, insertion or point mutation in specific amino acids which alters the intrinsic conformation of the protein, can ultimately lead to a fatal cancer disease. The protein tyrosine phosphatase has been recognized as a key regulator of extracellular stimuli such as cytokine receptor and...

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PMID: 30398108
DOI: 10.2174/1381612824666181106100837

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