Article

Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation

2020-10-30

Abstract excerpt

<h4>Background</h4> Chimeric antigen receptor (CAR) technology has revolutionized the treatment of B-cell malignancies and steady progress is being made towards CAR-immunotherapies for solid tumours. Epidermal growth factor family receptors EGFR or HER2 are commonly overexpressed in cancer and represent proven targets for CAR-T therapy; given their expression in healthy tissues it is imperative that any targeting...

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Literature Corpus work: daa1de31-b96d-5a51-ad73-b413fd53f2d9
DOI: 10.1101/2020.10.30.360925

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