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The Evolving Protein Engineering in the Design of Chimeric Antigen Receptor T Cells

27 Dec 2019

Abstract excerpt

The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in the treatment of haematological cancers has encouraged the extensive development of CAR design to improve their function and increase their applicability. Advancements in protein engineering have seen modifications to both the ecto- and endo-domains of the CAR, with recent designs targeting multiple antigens and including inducible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31892219
DOI: 10.3390/ijms21010204

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