Article

Kynurenic acid blunts A1 astrocyte activation against HIV-associated neurocognitive disorders

2022-09-22

Abstract excerpt

Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology. Here, we report that the robust activation of neurotoxic astrocytes (A1 astrocytes) in the CNS promotes neuron damage and cognitive deficits in HIV-1 gp120 transgenic mice. Notably, knockout of α7 nicotinic acetylcholine recep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da7d4d01-8785-524b-9052-18addd26545e
DOI: 10.21203/rs.3.rs-2064262/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kynurenic acid blunts A1 astrocyte activation against HIV-associated neurocognitive disordersDOI 10.21203/rs.3.rs-2064262/v1Read

Kynurenic acid promotes A1 to A2 astrocyte conversion against HIV-associated neurocognitive disorderSemantic proximity Read

The far-reaching HAND of cART: cART effects on astrocytes.Semantic proximity Read

A novel glia-immune humanized mouse model for investigating neuroimmune mechanisms in CNS HIV infection and diverse neurological disordersSemantic proximity Read

Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive DisorderSemantic proximity Read

A novel subtype of reactive astrocytes critical for HIV associated pain pathogenesisSemantic proximity Read

HIV-1 subtype B Tat enhances NOTCH3 signaling in astrocytes to mediate oxidative stress, inflammatory response and neuronal apoptosisSemantic proximity Read

HIV-1 Tat inhibits EAAT-2 through AEG-1 upregulation in models of HIV-associated neurocognitive disorderSemantic proximity Read

Identification of a novel subtype of astrocytes in HIV-associated pain pathogenesisSemantic proximity Read

Blocking Formation of Neurotoxic Reactive Astrocytes is Beneficial Following StrokeSemantic proximity Read

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic ImplicationsSemantic proximity Read

Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read

Analog of Kynurenic Acid Decreases Tau Pathology by Modulating Astrogliosis in Rat Model for TauopathySemantic proximity Read