Article

HIV-1 subtype B Tat enhances NOTCH3 signaling in astrocytes to mediate oxidative stress, inflammatory response and neuronal apoptosis

2023-04-26

Abstract excerpt

NOTCH receptors are relevant tomultiple neurodegenerative diseases. However, the roles and mechanisms of NOTCH receptors in HIV-associated neurocognitive disorder (HAND) remain largely unclear. Transactivator of transcription (Tat) induces oxidative stress and inflammatory response in astrocytes, thereby leading to neuronal apoptosis in the central nervous system. We determined that NOTCH3 expression was upregulat...

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Literature Corpus work: 317a777d-19c9-556d-a3a6-c5155ff068a5
DOI: 10.21203/rs.3.rs-2617583/v1

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