Article

Analog of Kynurenic Acid Decreases Tau Pathology by Modulating Astrogliosis in Rat Model for Tauopathy

2022-04-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and purpose</h4> Kynurenines have immunomodulatory and neuroactive properties and can influence the central nervous system. Previous studies showed the involvement of the kynurenines in the pathogenesis and progression of neurodegenerative disease. In neurodegenerative disorders, including tauopathies, the tryptophan metabolism is shifted toward neurotoxic agents and the reductio...

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Literature Corpus work: 1df1d76f-2fec-56b7-a505-9d9bc61ec68e
DOI: 10.1101/2022.04.19.488739

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