Article

Kynurenic acid promotes A1 to A2 astrocyte conversion against HIV-associated neurocognitive disorder

2022-07-11

Abstract excerpt

Although extensive astrocyte activation is present in the CNS of patients suffering from HIV-associated neurocognitive disorder (HAND), little is known about the contribution of reactive astrocytes to HAND neuropathology. Here, we report that the imbalance between neurotoxic (A1 astrocytes) and protective astrocytes (A2 astrocytes) occurring in HIV-1 gp120 transgenic mice impedes the resolution of inflammation in...

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Literature Corpus work: 7cdd8e12-1e21-5f26-b8b8-c827e4fdad9c
DOI: 10.1101/2022.07.11.499523

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