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Article

Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder

1 Jan 2010

Abstract excerpt

This review presents an up-to-date assessment of the role of the tryptophan metabolic and catabolic pathways in neurodegenerative disease and HIV-associated neurocognitive disorder. The kynurenine pathway and the effects of each of its enzymes and products are reviewed. The differential expression of the kynurenine pathway in cells within the brain, including inflammatory cells, is explored given the increasing...

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PMID: 22084594
DOI: 10.4137/ijtr.s4321

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