Article
A system for generating reversible knockout cell lines
2022-05-26
Abstract excerpt
A powerful use of gene editing technology is the generation of genetic-null (knockout) mutants of human immortalized cell lines. However, a problem that arises in the process of generating such edited lines is that to ensure edit homogeneity, clonal selection must often be performed and, given the genomic instability of immortalized cell lines and the high division number inherent to the clonal selection process,...
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Identifiers and source
- Literature Corpus work
- da6a62fe-44ee-55b6-928b-2fb23b5c2f4d
- DOI
- 10.1101/2022.05.25.493512