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An Alzheimer’s disease risk variant in <i>TTC3</i> modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons

2023-05-25

Abstract excerpt

A missense variant in the tetratricopeptide repeat domain 3 ( TTC3 ) gene (rs377155188, p.S1038C, NM_003316.4:c.3113C>G) was found to segregate with disease in a multigenerational family with late onset Alzheimer’s disease. This variant was introduced into induced pluripotent stem cells (iPSCs) derived from a cognitively intact individual using CRISPR genome editing and the resulting isogenic pair of iPSC lines...

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Literature Corpus work
579ed800-19e4-5ad7-8b7a-9837d4c734bd
DOI
10.1101/2023.05.25.542316
Open publication

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An Alzheimer’s disease risk variant in <i>TTC3</i> modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neuronsDOI 10.1101/2023.05.25.542316
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