Article
Accurate tumor clonal structures require single-cell analysis.
Annals of the New York Academy of Sciences - 1 Nov 2022
Su Xianbin, Bai Shihao, Xie Gangcai, Shi Yi, Zhao Linan, Yang Guoliang, Tian Futong, He Kun-Yan, Wang Lan, Li Xiaolin, Long Qi, Han Ze-Guang
Abstract excerpt
Tumor clonal structure is closely related to future progression, which has been mainly investigated as mutation abundance clustering in bulk samples. With relatively limited studies at single-cell resolution, a systematic comparison of the two approaches is still lacking. Here, using bulk and single-cell mutational data from the liver and colorectal cancers, we checked whether co-mutations determined by...
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