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Article

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

3 Apr 2017

Abstract excerpt

The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a clinical target against asthma calls for maximally harnessing its therapeutic potential via structural and mechanistic considerations. Here we employ an...

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Share to Allergic Rhinitis and Sensitization
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PMID: 28368013
DOI: 10.1038/ncomms14937

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