Article

Inhibition of striatal indirect pathway during second postnatal week leads to long lasting deficits in motivated behavior

2024-03-31

Abstract excerpt

Schizophrenia is a neuropsychiatric disorder with postulated neurodevelopmental etiology. Genetic and imaging studies have shown enhanced dopamine and D2 receptor occupancy in the striatum of patients with schizophrenia. However, whether alterations in postnatal striatal dopamine can lead to long lasting changes in brain function and behavior is still unclear. Here, we approximated striatal D2R hyperfunction in mi...

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Literature Corpus work: da16ae94-59e0-5646-aa91-f6fec580e01b
DOI: 10.1101/2024.03.29.586960

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