Article

Immp2l knockdown increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a mouse model of Tourette syndrome and autism spectrum disorder

2023-02-13

Abstract excerpt

Cortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms of autism spectrum disorder (ASD) and Gilles de la Tourette syndrome (GTS), such as tics and repetitive behaviours, may emerge because of imbalances in these neurocircuits. We have recently developed a model of ASD and GTS by knocking dow...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1decc751-c0ad-5afc-ada4-e860adf7f14f
DOI: 10.1101/2023.02.12.528225

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immp2l knockdown increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a mouse model of Tourette syndrome and autism spectrum disorderDOI 10.1101/2023.02.12.528225Read

Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibilitySemantic proximity Read

Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2Semantic proximity Read

Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in miceSemantic proximity Read

Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice.Semantic proximity Read

Cognitive deficits and altered cholinergic innervation in young adult male mice carrying a Parkinson's disease Lrrk2G2019S knockin mutation.Semantic proximity Read

Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson’s Disease LRRK2-G2019S Knockin MutationSemantic proximity Read

Integrative cross-species analyses identify deficits in habituation learning as a widely affected mechanism in AutismSemantic proximity Read

Neuronal deletion of CaV1.2 is associated with sex-specific behavioral phenotypes in mice.Semantic proximity Read

Assessment of behavioral flexibility in mice with conditional deletion of metabotropic glutamate receptor 2 from Emx1 -lineage neuronsSemantic proximity Read

Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models.Semantic proximity Read

Extensive characterization of a Williams Syndrome murine model shows Gtf2ird1 -mediated rescue of select sensorimotor tasks, but no effect on enhanced social behaviorSemantic proximity Read

Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.Semantic proximity Read